How Vivitrol Works
Vivitrol works by blocking the effect that opioids have on the brain, and reduces the cravings that many people experience after they quit. With alcohol, it is not certain how Vivitrol actually works, but it seems to change how the brain responds to alcohol consumption. Follow Now: Apple Podcasts / Spotify / Google Podcasts
Administration
You administer Vivitrol by intramuscular injection once a month. One of the main problems with the daily dosages of naltrexone was medication compliance; patients had to remember and be willing to take the pills each day. With the once-a-month shot, medication compliance is less of a factor in the treatment plan.
Is Vivitrol Right for You?
Patients already completely detoxed from alcohol and opioids are candidates for Vivitrol. It is not intended to help someone stop drinking. According to the FDA, patients “must not have any opioids in their system when they start taking Vivitrol; otherwise, they may experience withdrawal symptoms from the opioids. Also, patients may be more sensitive to opioids while taking Vivitrol at the time their next scheduled dose is due. If they miss a dose or after treatment with Vivitrol has ended, patients can accidentally overdose if they restart opioid use.”
Vivitrol vs. Other Medications
Vivitrol is the first non-narcotic, non-addictive, extended-release medication approved for the treatment of opioid dependence. Methadone and buprenorphine, also approved for opioid addiction treatment, can be addictive. Methadone is available only through specialized clinics. Buprenorphine is available through doctors’ offices, but it and methadone require daily doses.
Side Effects
According to the FDA, side effects of Vivitrol during trial studies include:
DizzinessHeadacheMuscle crampsNausea and vomitingPainful jointsTiredness
Other potentially serious side effects of Vivitrol include:
Allergic reactions, such as hives, rashes, facial swellingFeeling depressedLiver damagePneumoniaReactions at the injection site, which can be severe and may require surgical interventionSuicide, suicidal thoughts, and suicidal behavior
Alkermes, the drug’s manufacturer, claims the main side effects are: For more mental health resources, see our National Helpline Database.
Increased liver enzymesInflammation of nasal passagesInsomnia
Effectiveness
Vivitrol works best in conjunction with an overall treatment program. Research shows it is more effective than medications requiring a daily dose and double-blind, placebo-controlled clinical trials show Vivitrol effectively prevents relapse and reduces drug cravings. FDA trials found Vivitrol patients are more likely to stay in treatment and to refrain from using illicit drugs and 36 percent were able to stay in treatment for the full six months without using drugs, compared with 23 percent in the placebo group.
